Carvedilol significantly reduced mortality from cardiovascular causes and Study Rundown: The CAPRICORN trial demonstrated that. London, UK – Results of the CAPRICORN trial confirm the benefit of the beta blocker carvedilol (CoregĀ® – GlaxoSmithKline) in reducing. Description: The CArvedilol Post-infaRct survIval COntRolled evaluatioN ( CAPRICORN) trial was a randomized, placebo-controlled trial.

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CAPRICORN – Wiki Journal Club

The Lopressor Intervention Trial: Effect on mortality of metoprolol in acute myocardial infarction. Intravenous nitroglycerin therapy to limit myocardial infarct size, expansion, and complications. A randomised trial of propranolol in patients with acute myocardial infarction, I: Effects of carvedilol early after myocardial infarction: Keywords myocardial infarction, beta-blocker, carvedilol, metoprolol.

Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: Center for Drug Evaluation and Research, U.

A placebo-controlled, randomized trial. Beneficial effects of intravenous and oral carvedilol treatment in acute myocardial infarction. Effect of timing, dosage, and infarct location. Acute myocardial infarction complicated by systemic hypoperfusion without hypotension: Effects on mortality during five years after early intervention with metoprolol in suspected acute myocardial infarction.


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Clopidogrel and metoprolol in myocardial infarction. After myocardial infarction carvedilol improves insulin resistance compared to metoprolol.

This work is licensed under a Creative Commons Attribution 4. Randomised trial of intravenous atenolol among 16 cases of suspected acute myocardial infarction: A double-blind randomized trial. Rational Pharmacotherapy in Cardiology. Basic Clin Pharmacol Toxicol ; 2: These beneficial effects are additional to those of evidence-based treatments for acute myocardial infarction including ACE inhibitors.

Email the author Login required. Study medication was progressively increased to a maximum of 25 mg twice daily during the next weeks, and patients were followed up until the requisite number of primary endpoints had occurred.


J Am Coll Cardiol ;49 9: Email this article Login required. Keywords acute coronary syndrome ambulatory blood pressure monitoring amlodipine apixaban arterial hypertension atherosclerosis atrial fibrillation beta-blockers cardiovascular diseases chronic heart failure hypertension ischemic heart disease lisinopril metabolic syndrome myocardial infarction obesity risk factors rivaroxaban statins stroke warfarin.

Body weight changes with beta-blockers use: Generally, the patients recruited to these trials were at low risk: Editor in chief Boytsov S. MoscowRussia Petroverigsky per. We investigated the long-term efficacy of carvedilol on morbidity and mortality in patients with left-ventricular dysfunction after acute myocardial infarction treated according to current evidence-based practice.


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Data of the studies comparing influence of metoprolol tartrate and carvedilol on MI pathogenesis are presented. Article Tools How to cite item. Clin Res Cardiol ;95 1: Int J Cardiol ;10 3: Eur Heart J ;8 The primary endpoint was all-cause mortality or hospital admission for cardiovascular problems.

Carvedilol protects better against vascular events than metoprolol in heart failure: Eur Heart J ;29 Pacing Clin Electrophysiol ;28 Suppl 1: Clin Res Cardiol ;95 2: Am J Med ; 5: Last changes in guidelines regarding beta-blockers prescription to patients with MI are presented. Carvedilol versus metoprolol in patients undergoing direct percutaneous coronary interventions for myocardial infarction: