Slide 2 of 5 of Coagulación sanguínea. VÍA EXTRÍNSECA; 2. Vía Intrínseca; 3. Conversión de la Vías y cascada de la coagulación. Enzimas que actuan en la coagulación.c. Asignatura: .. Al final, las vías intrínse cas y extrínsecas confluyen en una secuencia de etapas en común. hasta. Los factores de la coagulación de la vía extrínseca se activan al producirse el La coagulación también puede activarse por la vía intrínseca al entrar en.

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Forty nine seaweed species collected off casccada of several localities of Gulf of Mexico and Mexican Caribbean sea were screened in order to detect anticoagulant activity intrjnseca both intrinsic and extrinsic pathways of clot formation. The sites of collection of Veracruz state were: Seasonal variations in the production of antifungal substances by some dictyotales brown algae from the French Mediterranean coast.

Purification and characterization of a fibrinolytic enzyme and identification of fibrinogen clotting enzyme in a marine green alga Codium divaricatum.

Similar results of slightly anticoagulant potency were observed but in thrombin time test for C. This is the first report of anticoagulant activity in Anadyomene stellataLobophora variegata and Liagora farinosa.

Our results showed four species with similar activity susceptible of further research for isolation and characterizations of active substances. Finally, sample collected in April of change the anticoagulant activity been active only in the thrombin time test. It is not common that extracts from algae were active in both tests, in the literature are only few examples as Codium fragile subsp. However we consider more research has to be done, focused to this topic, in order to probe this hypothesis.


Detección de sustancias anticoagulantes en algunas macroalgas marinas

Screening for anticoagulant substances in some marine macroalgae. Se reporta por primera vez la actividad anticoagulante de Anadyomene stellataLobophora variegata y Liagora farinosa. These localities were chosen due to the relative abundance of the algae. Seasonal variation of antibacterial and antifungal activities of the extracts of marine algae from southern coasts of India.


Recently, a group of scientists had stand out the potentiality of some proteins and proteoglycans capable of interfere with blood clotting cascade, particularly from Codium Matsubara et al. These variation has been suggested as been influenced by geographical factors such as climate and locality and has been probed with primary metabolites as lectins by Ingram and Fabregas et al.

The results showed other algae with slightly inhibition of clot formation activity, it is not common to consider this species for further investigation, nevertheless the retardation of formation of clot by Penicillus capitatusa species evolutionary related to Halimeda genus Vroom et al.

Journal of Applied Phycology Chemical structure of antithrombin-active Rhamnan sulfate from Monostroma nitidum. We also detected a variation in the anticoagulant potency, a change in the anticoagulant activity related with the intrinsic or extrinsic pathways of coagulation or even the disappearance of the anticoagulant activity in both test of Caulerpa cupressoidesC.

A simple method of studying the generation of thrombin in recalcificated plasma.

Thrombosis Research 55 3: This last intrinsca is a sulfated glicosaminoglycan used in oral therapy for anticoagulant disorders. Nucleic Acids Research 19 This fact makes the discovery of new anticoagulant substances a priority issue in research.

British Phycological Journal The New England Journal of Medicine 3: El factor IXa, por otro lado, activa al factor X.

Factor de coagulación XI

Journal of Biological Chemistry SPB Academic Publishing bv. Inhibition of thrombin by sulfated polysaccharides isolated from green algae. Comparative Biochemistry and Physiology B: Anticoagulant and antithrombin activities of oversulfated fucans.


Revista de la Sociedad Mexicana de Historia Natural It is relevant to point out the dependence of anticoagulant potency due to the locality where algae grows, also the date of collection and thus, the climate season is other factor that could influence the synthesis of compounds, particularly in the brown alga Lobophora variegata we observed the double anticoagulant action in sample collected in May ofbut six months later Novembersame specie only was active in the prothrombin time test.

Rhamnan sulfate from cell walls of Monostroma latissimum. El gen de FXI tiene una longitud de coaguladion kb, posee 15 exones, y se encuentra en el brazo largo del cromosoma 4 4q Tissue factor pathway inhibitor.

Cada cadena posee una masa molecular de aproximadamente 80 One of the extracts of C. A delay in clot va less than two minutes was observed in prothrombin time test for this species from Chlorophyta: Anticoagulant, fibrinolytic and antiaggregant activity of carrageenans and alginic acid.

Occurrence of heparin in the invertebrate Styela plicata Tunicata is restricted to cell layers facing the outside environment. An International Journal in Haemostasis and Thrombosis 16 4: Agardh, ChlorophytaLobophora variegata Lamoroux Womersley Phaeophyta and Liagora farinosa Lamouroux Rhodophyta were as potent as heparin impeding the clot formation in both thrombin and prothrombin time tests.

Biochemical and Biophysical Research Communications 2: Cytogenetics and Cell Coagu,acion 52 We considered an algal extract with anticoagulant activity similar to heparin when this impede the clot formation during 10 minutes or more.