In , Koebner coined the term epidermolysis bullosa hereditaria. In the late nineteenth and early twentieth centuries, Brocq and Hallopeau. Inherited epidermolysis bullosa (EB) encompasses a number of disorders characterized Epidermolysis bullosa hereditaria; Hereditary epidermolysis bullosa. Inherited epidermolysis bullosa (EB) encompasses a number of disorders Disease name: epidermolysis bullosa EB hereditaria.

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Journal of the American Academy of Dermatology.


Similar articles in PubMed. Decreased frequency of blistering occurs during mid- to late childhood and blistering may be a minimal component of the disorder in adult life. There is no cure for the condition.

Dyskeratosis as a histologic feature in epidermolysis bullosa simplex-Dowling Meara. Capillary hemangioma Port-wine stain Nevus flammeus nuchae.

Epidermolysis bullosa

Many individuals with EBS, in contrast to those with junctional EB and dystrophic EB, find that excessive bandaging may actually lead to more blistering, presumably as a result of increased heat and sweating.

Typically, heterozygous sibs of a proband with autosomal recessive EBS are unaffected; however, phenotypically similar ectodermal dysplasia syndromes see Genetically Related Disorders can be caused by heterozygosity for pathogenic variants associated with autosomal recessive EBS [ Betz et alLugassy et alLiao et alSprecher et al ].

Epidermolysis bullosa hereditaria Hereditary epidermolysis bullosa Prevalence: No phenotypes other than those discussed in this GeneReview are known to be associated with pathogenic variants in EXPH5. However, antibodies to exophilin 5 and transglutaminase 5 are not widely available, limiting the clinical utility of this study to the exceedingly rare forms of EBS-AR caused by biallelic pathogenic variants in KRT Epidermolysis bullosa simplex associated with pyloric atresia is a novel clinical subtype caused by mutations in the plectin gene PLEC1.


Within basal keratinocytes, plectin is localized to the inner plaques of the hemidesmosomes, which are hypoplastic and show poor association with keratin filaments.

TGM5 encodes the transglutaminase 5 enzyme, which is strongly expressed in the epidermal granular cells, where it crosslinks a variety of structural proteins in the terminal differentiation of the epidermis to form the cornified cell envelope the outermost layer. If the balance of production could be shifted away from the mutated, dysfunctional keratin gene toward an intact keratin gene, symptoms could be reduced.

Antenatal diagnosis Molecular prenatal diagnosis may be available if the disease-causing mutation in the family has been identified. The palms epidermolisks soles are usually more involved than the backs of the hands and the tops of the feet.

University of Washington, Seattle ; Management and treatment Optimal patient management requires a multidisciplinary approach, and revolves around the protection of susceptible tissues against trauma, use of sophisticated wound care dressings, aggressive nutritional support, and early medical or surgical interventions to correct the extracutaneous complications, whenever possible. The documents contained in this web site are presented for information purposes only.

The molecular genetics of the genodermatoses: Epidermolysis Bullosa Acquisita, Epidermolysis Bullosa. Prevalence The prevalence of EBS is uncertain; estimates range from 1: As of clinical research at the University of Minnesota has included a bone marrow transplant to a 2-year-old child who is one of 2 brothers with EB.

Thus, there is a risk in affected individuals with less severe disease that a blister may not be induced and the biopsy may be non-diagnostic.

Dominant-negative missense variants predominate and often affect the ability of the keratin to associate with its keratin partner, its secondary structure, and its ability to form the intracellular network. EXPH5 encodes the amino acid protein exophilin-5, a Rab27 effector protein.


From Wikipedia, the free encyclopedia. Back Links pages that link to this page. Diagnosis Suggestive Findings The diagnosis of epidermolysis bullosa simplex EBS should be suspected in individuals with the following clinical findings: PMC ] [ PubMed: In the late nineteenth and early twentieth centuries, Brocq and Hallopeau coined the terms traumatic pemphigus, congenital traumatic blistering, and acantholysis bullosa; these terms are no longer in use [ Fine et al ].

The ability to induce blisters with friction although the amount of friction can vary and to enlarge blisters by applying pressure to the blister edge is common to all; mucosal and nail involvement and the presence or absence of milia may not be helpful discriminators.

Blistering epidermmolisis be severe and granulation tissue can form on the skin around the oral and nasal cavities, fingers, and toes, and internally around the upper airway. The human skin consists of two layers: These changes tend to develop on the trunk particularly in large skin folds such as the neck, groin, and axillae and then on the extremities. Antibodies to keratin 5 or keratin 14 and other dermal-epidermal junction antigens typically laminin and type VII collagen show localization of stained epitopes to the blister floor.

Epidermolysis bullosa – Wikipedia

The mucosa can be involved; this usually improves with age. Consultation with a dermatologist to evaluate the sites of blister formation, including oral mucosa. How the abnormal gene product causes this disruption is unknown. University of Washington, Seattle;