Disease definition. Fetal hydantoin syndrome is a drug-related embryofetopathy that can occur when an embryo/fetus is exposed to the anticonvulsant drug. A clinical diagnosis of fetal hydantoin syndrome secondary to in utero phenytoin exposure was considered. Investigations showed vitamin D. This page includes the following topics and synonyms: Fetal Hydantoin Syndrome.

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Postoperative view, corrected developing crossbite Click here to view. Fetal hydantoin syndrome is a characteristic pattern of mental and physical birth defects that results from maternal use of the anti-seizure anticonvulsant drug phenytoin Dilantin during pregnancy.

Fetal hydantoin syndrome – Wikipedia

Maternal use of anti-seizure medications such as phenytoin, which is often used to treat epileptic seizures, can result in multiple effects on the developing embryo and fetus, including fetal hydantoin syndrome.

N Engl J Med.

Clinical of fetal syndrome Hanson, [6] Click here to view. As affected children grow older, the developmental delays improve, but studies suggest that children may remain slightly behind unexposed siblings.

Researchers believe that the protein product of this gene plays a role in the hdantoin breakdown metabolism of phenytoin or one of its metabolites. Together we are strong.

Fetal Hydantoin Syndrome – NORD (National Organization for Rare Disorders)

Definition NCI A teratogenic disorder observed in a newborn or child of a mother who was exposed to phenytoin during pregnancy.


Syndromee to mild intellectual disability has been reported in some cases, and some studies have suggested that children exposed to phenytoin in the womb have a greater risk of developing learning disabilities, particularly in verbal skills.

Various methods of rehabilitative and behavioral therapy may be beneficial.

The content of the website and databases of the National Organization for Rare Disorders NORD is copyrighted and may not be reproduced, copied, downloaded or disseminated, in any way, for any commercial or public purpose, without prior written authorization and approval from NORD. High hyydantoin palate Click here to view.

Signs Microcephaly Growth delay Mental Retardation and Developmental Delay Craniofacial dysmorphic features Flat nasal bridge Epicanthic folds Prominent upper lip over wide mouth Distinguishing characteristics Nail and distal phalanx hypoplasia Hypertelorism.

An umbilical hernia is when the intestines or fatty tissue pushes through the area near the bellybutton. Retrieved from ” https: Infants with fetal hydantoin syndrome can benefit from early developmental intervention to ensure that affected children reach their potential.

Reports in the medical literature disagree as to the likelihood of infants with fetal fstal syndrome experiencing developmental delays or intellectual disability.

Additional information Further information on this disease Classification s 6 Gene s 0 Clinical signs and symptoms Publications in PubMed Other website s 3.


None, Conflict of Interest: The specific amount of phenytoin ingestion required to cause the disorder has not been determined. Growth deficiency may be mild to moderate in severity and can continue during the newborn period postnatal growth deficiency. An increased number of fingerprint arches have also been noted. Chronic developmental exposure to phenytoin has long-term behavioral consequences.

Syndromes of the Head and Neck. Limping walk Click hydanhoin to view.

Other anti-seizure medications can cause a characteristic pattern of mental and physical birth defects similar to those seen in infants exposed to phenytoin during pregnancy. Treatment for epilepsy in pregnancy: Content is updated monthly with systematic literature reviews and conferences. Right side in occlusion Click here to view.

Rare Disease Database

Search Bing for all related images. Fetal hydantoin syndrome may be caused by hydanfoin combination of specific genetic and environmental factors. Related articles Anticonvulsants crossbite phenytoin space maintainer. Radiograph of 85 Click here to view. Foetal antiepileptic drug exposure and verbal versus non-verbal abilities at three years of age.