Autoimmune hepatitis (AIH) is also known historically as chronic aggressive hepatitis, plasma cell hepatitis, lupoid hepatitis and chronic active hepatitis. Am J Med Sci. Apr;(4) doi: / Epub Nov 4. Lupus Hepatitis and Autoimmune Hepatitis (Lupoid Hepatitis). Autoimmune hepatitis is a disease in which the body’s immune system attacks liver cells. This immune response causes inflammation of the liver, also called.

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It has been used for many years and tends to work for many. Physical exam may be normal. No dose adjustments are necessary but patients with cirrhosis are felt to be more refractory to drug therapy for AIH and therefore higher doses of azathioprine may be attempted. Related Disorders Other disorders can have similar symptoms to autoimmune hepatitis and need to be considered when making a diagnosis. This content does not have an Arabic version.

Some preparations have a special coating on them and can be taken just before, or after, food. A few environmental triggers, such as prescribed medications and infections, have been associated with the development of AIH.

Autoimmune hepatitis (lupoid hepatitis, chronic active hepatitis) – Cancer Therapy Advisor

Antibodies associated with AIH include:. Rarely, rash or unexplained fever may appear. Treatment can slow down, stop, and sometimes reverse liver damage. Diagnosis of AIH can be complex, and is frequently completed after going through several steps. This content does not have an English version. AMA may sometimes be seen although are typically seen in primary biliary cirrhosis. Complications of autoimmune hepatitis. At this time, the exact cause of autoimmune hepatitis is unknown.

If you have a relapse or flare liver tests increase while on therapy then steroids are either restarted or the dose is increased if you are already taking them. Screening for hepatocellular carcinoma is performed in patients with cirrhosis from AIH. Methotrexate, rapamycin, rituximab, and infliximab have been used in a small subset of patients with AIH who did not respond well to the drugs discussed above. Azathioprine can result in nausea, vomiting and diarrhea that may exacerbate symptoms from pre-existing gastrointestinal disease.


For information about clinical trials sponsored by private sources, contact: Most medicines are processed by the liver so they can be toxic to people with liver problems.

Autoimmune hepatitis – Wikipedia

Increased bilirubin may indicate severe inflammation associated with the disease, but may also indicate decreased liver function. Just why the body helatitis against itself is unclear, but researchers think autoimmune hepatitis could be caused by the interaction of genes controlling immune system function and exposure to particular viruses or drugs.

It can be quite technical, so please discuss any content that you are unsure about with your medical team.

Liver biopsy for this condition typically shows fatty heatitis, presence of polymorphonuclear leukocytes and central fibrosis. The anti-smooth muscle antibody ASMA test is used to diagnose autoimmune hepatitis and distinguish it from other causes of liver damage.

Histology demonstrates lymphoplasmacytic portal infiltrate. Autoimmune hepatitis AIH is also known historically as chronic aggressive hepatitis, plasma cell hepatitis, lupoid hepatitis and chronic active hepatitis. Once treatment has started it is long-term, for at least two years and lupokd is usually lifelong. A liver biopsy is done to help confirm autoimmune hepatitis and also to stage the amount of fibrosis present. Retrieved October 9, Your doctor will prescribe a dose tell you how much of the medication for you to take; this will depend on your weight and condition.

Ultimately, it can lead to liver failure. Autoimmune hepatitis is liver inflammation that occurs when your body’s immune luloid turns against liver cells. Type 2 is more common lupoiv children and often involves a more severe disease process.


Infliximab and rituximab are also under evaluation for treatment of AIH. Untreated autoimmune hepatitis can lead to scarring of the liver cirrhosis and eventually to liver failure. From Wikipedia, the free encyclopedia.

Blood tests can also measure the amount of immunoglobulin G IgG antibodies in your blood. Exclude by measurement of hepatic iron concentration and HFE mutations.

Looking after yourself Alcohol Alcohol is a toxin processed by your liver and, as a result, it can be dangerous for anyone with liver problems. Evaluate complications of chronic liver disease by looking for ascites, skin findings or hepatic encephalopathy. Primary biliary cholangitis PBC: Standard Therapies Treatment Those with AIH are usually started on corticosteroids and then placed on other immunosuppressive agents.

Other autoimmune conditions can cause symptoms of liver disease and are also associated with the development of AIH. Primary sclerosing cholangitis PSC: Even trying to cut back on the sweet stuff….

Rare Disease Database

Some medications can also trigger Autoimmune Hepatitis. Anomalous presentation of MHC class II receptors on the surface of liver cells, [2] possibly due to genetic predisposition or acute liver infectioncauses a cell-mediated immune response against the body’s own liver, resulting in autoimmune hepatitis.

Common initial symptoms can include fatigue, nausea, vomiting, bepatitis pain, weight loss, light colored stools, dark colored urine, joint pain, rashes, and loss of menstruation in women.

Complementary and alternative medicines and therapies Many complementary and alternative medicines available suggest they can ease the symptoms of liver disease. When symptoms do start to appear, they often start over weeks or months.